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A complete of 3 % of Lively material is excreted in urine as unchanged Energetic compound. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which happen to be further more metabolised by conjugation. Consequently, Lively material metabolism mediated by cytoc

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